What would you do? Failed FET and low grade embryo

I’m after a bit of advice/opinion… a few years ago we underwent two rounds of ICSI (failed fresh transfer followed by successful FET). This year we decided to try for our second with our one of two remaining embryos 5ABC. Unfortunately the FET was unsuccessful and we now have one 5BBC embryo remaining. We are debating whether we should proceed with the remaining embryo at another cost of £3k or start the whole process again and try to get better grade embryos, costing about £6k. Obviously it isn’t pennies, and I’m worried that if we use our final embryo and it also doesn’t work, we’ll kick ourselves knowing it was a lower grade. On the other hand, the thought of going through the whole egg collection process again is really daunting. We have male factor infertility and I’m worried what if his sperm count/quality has decreased even more over the past few years. What would others do? And if you have any success stories with lower grade embryos, please do share 🙏🏼 feeling so deflated and unsure
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I haven’t seen embryos graded with three letters before but BB is not a low grade embryo. My son was a 2BB and yours is even more expanded based on the number. The quality of an egg is most affected by age so without having that info it’s hard to give advice. What you might want to consider is whether you want more than two children and if so you might want to bank more embryos now as you won’t get the chance to for a few years if you’re successful with a transfer on the frozen one. Sperm quality can improve through lifestyle changes. We’ve been told many times that the grade of an embryo isn’t that important, if it can be frozen it can create a baby.

@Naz the 5 relates to the embryo being frozen on day 5 so not sure if it means it’s more expanded (unless both things correlate). And not sure if you mean my age (27 at the time of freezing) or how long it’s been frozen (4 years) but I’m glad to hear you were successful with a 2BB embryo. Our Dr previously told us our chances were reduced with the final embryo so I’ve no idea what to think! And I hadn’t even thought about whether we’d want more children further down the line! Thank you for your comments.

In the grading system I’m familiar with and the most common one, the number refers to the expansion of the cavity at the time of freezing not that it’s a day 5 blast. Embryos can expand upon thaw too so the number isn’t as significant as the letters. The earlier you create embryos the better the chances but early 30s is still young and gives you time to do ivf in a few years if you wanted to. I wouldn’t discount that embryo.

I imagine 5bbc is same as 5bc my embryo that I’m 14 weeks with is 5bc we got no super high quality embryos but I’ve heard of plenty of ppl with success from lower grade even mosaic embryos

Most of my friends who were going for baby no.2 did another collection so they had more than one embryo banked. I think it’s sensible. I think it would be harder mentally to do a collection after you have had a failed round with your last embryo. Ivf is just a numbers game at the end of the day!

This really depends on your risk assessment, as it may cost you a lot more than 3K or 6K, because there’s also the scenario where your next cycle doesn’t work, and when you need to do more FETs you may again turn to the existing embryo! I guess at that point you may find the decision to start fresh a bit stupid? I guess if I were you I’d still give that embryo a chance before starting all over again! Btw we were extremely risk averse so paid 9K for a 2 cycle package (I was 38), and this ended up being a good decision (had 2 egg collections, 1 fresh and 3 FETs). Sadly I didn’t qualify for any refund packages otherwise I’d totally go for those!

@Isabela that is reassuring, and congratulations!

@Francesca that’s a good point about banking more. And you’re right, it’s just a game of chance which is so frustrating!

@Wanyu this is why I’m so unsure at the moment, there are a good few options but everything costs a lot of money and takes a lot of time and there’s no guarantee any of it will work! We’ve started looking at some of the packages but haven’t got to the criteria stage, were the refund packages quite strict? Sounds like you went through a lot but glad you were successful in the end 🙂

I guess the thing that’s confusing to me is why do another whole round because this embryo may or may not be low quality, when the quality of new embryos will probably be lower now anyway now that years have past? If you might want 3 kids I could see going straight to another round

There’s age limit for the refund programme in my clinic it was 37 if I remember correctly

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