Failed transfers (tests before 5th try!)

Are they suggesting testing already frozen embryos?? That is not usually recommended as this may further damage them. ERA may be worth doing, and I’d suggest immunological investigation - such as NK cells etc. In my case they checked mine and added steroids, intralipid and Inhixa to my protocol.

And I’m now 9 weeks (after 3 early miscarriages & 3 failed transfers).

@Wanyu yes they’ve suggested it, he did mention that risk but he said the risk is about 10% I asked about this but he said it’s now not routinely tested so good knows! Congratulations that’s wonderful news x

I had three failed transfers (1 fresh and 2 frozen) I requested to have laparoscopic surgery as I didn't know what else to try. To my surprise, endometriosis was found and removed (I never had any symptoms) For my fourth transfer my clinic (in the US) did this: First 5 days of the FET cycle I took doxycycline 100 mg (antibiotic) Starting on the day of transfer Prograf 1 mg twice a day until positive pregnancy test 50mg levothyroxine (my clinic wants the TSH value to be below 2 uIU/ml) 10 mg Prednisone (2x day since day 1) LDN 4.5 mg (since day 1) Lovenox 30 mg (since day 1) Over the counter medications:Claritin 10 mg, Pepcid 20 mg, Aspirin 81 mg, Benadryl 25 mg and prenatal vitamins+ vitamin d Estrace and progesterone I don't know what worked, if the surgery or any or all the meds but I am currently 6w4d pregnant.

@Leslie thank you for the information I appreciate it and congratulations great news x

I’m sorry you are going through this. I have not had a baby ever but had two failed FETs last year with tested embryos. After that I’ve done LOADS of tests and have now just received a positive result with my third transfer (though extremely early days) Here’s what I checked: ERA - was normal and very little evidence around this too EMMA /ALICE - checks the microbiome of the uterus - mine was normal but prior to that I had been doing vaginal probiotics so that may have helped Hysteroscopy- I strongly recommend this even if you have had a baby before as it may pick up on scar tissue or other things that may have happened at your last birth or since and it also tests for endometrisis (not osis) which is an infection of the endometrium. Mine was ok but they found I had a narrow uterus and were able to expand a little during the procedure. Lots of immune blood tests: some of these came back positive and so I was seen by a reproductive immunologist and am now on…

… steroids, blood thinners and metformin (for inflammation and insulin balance). I also did a mild stimulated FET (stimulate ovaries slightly to create leading follicle and then trigger ovulation and supplement progesterone) as opposed to a fully medicated FET which I did last time which has this time increased my lining thickness and my progesterone as there is natural progesterone too. So as you can see I tested nearly everything! So who knows what specifically has worked to help me implant this time but something did! And it certainly gave me a bit more peace of mind. Anyway wishing you so much luck!

@Charlie thank you Charlie that’s all really good information I will bring forward! Congratulations to you! X

Hi Guys Sorry to jump in but I found this thread to be super helpful! I’ve just had a failed FET (implantation failure) and struggling to think about the next steps. Really curious about immunology testing and wanted to know if you all did a biopsy or found it useful by just testing blood. As it’ll be my second cycle, I don’t want go down the extreme route yet and perhaps try experimenting with medication eg steroids, intralipids, probiotics etc. than splurging 1000s on tests which are also ok the red light as per HFEA. Anyone went through this route or only testing first and then experimenting with medication. Thanks a ton in advance.

@Shimmie my consultant only investigated immunological issues after 2-3 early miscarriages or recurrent implantation failures with top graded embryos. They believe that most failures are due to embryo quality(~80% I read it somewhere in scientific medical papers as I’m a researcher by training), which without PGT would be difficult to know. Even with PGT it’s just screening so not 100% accurate! Most immunological issues can be tested with blood tests alone but these tests are not cheap. Uterine problems may require further investigations than bloods but without any history of miscarriages it may not be necessary because chances are much lower. I would say discuss with your doctor and trust their judgment!